| Title: | Human lifespan is linked to truncating variants in single genes |
| Journal: | Nature Aging |
| Published: | 3 Mar 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37117741/ |
| DOI: | https://doi.org/10.1038/s43587-022-00197-w |
| URL: | https://www.nature.com/articles/s43587-022-00197-w.pdf |
Publication 8170
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Abstract
Life expectancy is partially determined by an individual's genetic make-up. Whole-exome sequencing analysis of >350,000 UK Biobank participants revealed that protein-truncating variants in four genes, BRCA1, BRCA2, ATM and TET2, are negatively associated with human lifespan. Phenome-wide analyses confirm roles for these genes in cancer and clonal hematopoiesis.Enabling scientific discoveries that improve human health