| Title: | The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders |
| Journal: | Cell Genomics |
| Published: | 25 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36819664/ |
| DOI: | https://doi.org/10.1016/j.xgen.2022.100249 |
Publication 7975
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Abstract
Phenotypic associations have been reported between blood cell traits (BCTs) and a range of neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether these associations have a genetic basis and, if so, to what extent genetic correlations reflect causality. Here, we report genetic correlations and Mendelian randomization analyses between 11 NPDs and 29 BCTs, using genome-wide association study summary statistics. We found significant genetic correlations for four BCT-NPD pairs, all of which have prior evidence for a phenotypic correlation. We identified a previously unreported causal effect of increased platelet distribution width on susceptibility to Parkinson's disease. We identified multiple functional genes and regulatory elements for specific BCT-NPD pairs, some of which are targets of known drugs. These results enrich our understanding of the shared genetic landscape underlying BCTs and NPDs and provide a robust foundation for future work to improve prognosis and treatment of common NPDs.10 Authors
- Yuanhao Yang
- Yuan Zhou
- Dale R. Nyholt
- Chloe X. Yap
- Rudolph K. Tannenberg
- Ying Wang
- Yang Wu
- Zhihong Zhu
- Bruce V. Taylor
- Jacob Gratten
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
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