| Title: | Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank |
| Journal: | International Journal of Environmental Research and Public Health |
| Published: | 29 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36767787/ |
| DOI: | https://doi.org/10.3390/ijerph20032421 |
| URL: | https://www.mdpi.com/1660-4601/20/3/2421/pdf?version=1675823826 |
| Citations: | 9 (9 in last 2 years) as of 8 Aug 2024 |
Publication 7971
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Abstract
OBJECTIVE: This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex.</p>
METHODS: In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail individuals categorized by sex.</p>
RESULTS: Lower concentrations of apoA1, total, LDL, and HDL cholesterol, albumin, eGFRcys, vitamin D, total bilirubin, apoB, and testosterone (differences ranged from -0.30 to -0.02 per 1-SD change), as well as higher concentrations of triglycerides, GGT, cystatin C, CRP, ALP, and phosphate (differences ranged from 0.01 to 0.53 per 1-SD change), were identified both in pre-frail and frail men and women. However, some of the associations differed by sex. For instance, higher rheumatoid factor and urate concentrations were identified in pre-frail and frail women, while lower calcium, total protein, and IGF-1 concentrations were identified in pre-frail women and frail women and men. When the analyses were further adjusted for CRP, similar results were found.</p>
CONCLUSIONS: Several biomarkers were linked to pre-frailty and frailty. Nonetheless, some of the associations differed by sex. Our findings contribute to a broader understanding of the pathophysiology of frailty as currently defined.</p>
9 Authors
- Wenying Chu
- Nathan Lynskey
- James Iain-Ross
- Jill P. Pell
- Naveed Sattar
- Frederick K. Ho
- Paul Welsh
- Carlos Celis-Morales
- Fanny Petermann-Rocha
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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