| Title: | Associations of high-normal blood pressure and impaired fasting glucose with atrial fibrillation |
| Journal: | Heart |
| Published: | 7 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36750354/ |
| DOI: | https://doi.org/10.1136/heartjnl-2022-322094 |
Publication 7955
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Abstract
OBJECTIVE: To investigate the association of high-normal blood pressure (BP) and impaired fasting glucose (IFG) with the risk of atrial fibrillation (AF) in two cohorts. METHODS: The Korean National Health Insurance Service-Health Screening (K-NHIS-HealS, 2002-2003, follow-up until 2013) Study and the UK Biobank (2007-2010, follow-up until 2021) were evaluated. We used Cox proportional hazards regression models to evaluate the associations of high-normal BP and IFG with incident AF. RESULTS: In the K-NHIS-HealS and the UK Biobank, 2346 and 5314 incident AF events were recorded during the mean follow-up of 7.4 and 11.8 years. The adjusted HRs (95% CIs) for AF in the Korean and UK cohorts were 1.11 (1.02 to 1.21) and 1.07 (1.01 to 1.13) in individuals with high-normal BP; and 1.14 (1.04 to 1.25) and 1.10 (1.01 to 1.20) in individuals with IFG, respectively. The AF risk showed a dose-response relationship with BP and fasting blood glucose level. The risk of incident AF was increased by the combination of high-normal BP and IFG. CONCLUSIONS: In healthy individuals, high-normal BP and IFG were important risk factors for AF. When high-normal BP and IFG were combined, the risk of new-onset AF was significantly increased. These findings may suggest that lifestyle interventions for high-normal BP and IFG should be considered to reduce the risk of AF.10 Authors
- Juntae Kim
- Dongmin Kim
- Eunsun Jang
- Daehoon Kim
- Seng Chan You
- Hee Tae Yu
- Myung-Yong Lee
- Gregory Lip
- Pil-Sung Yang
- Boyoung Joung
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