WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Impairment of cognitive function (e.g. reasoning, memory and speed) in people with mood disorders has previously received less research and clinical attention than impairment in schizophrenia and neurological conditions. We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson s disease, within the UK Biobank cohort. After taking into account age and gender differences, direct comparisons in the present study indicated that, relative to participants with no history of psychiatric or neurological conditions, cognitive impairment was least common in major depression and most common in schizophrenia. Impairment prevalence in mania/bipolar disorder was similar to that in multiple sclerosis and Parkinson s disease, both of which are much less common in the population. The high population prevalence of major depression means that the overall burden of cognitive impairment attributable to this disorder is likely to be considerable. A limitation of the study is that information regarding psychiatric and neurological history relied substantially on self-reported diagnoses or responses to questionnaire items. Also, the UK Biobank cohort is not representative of the UK population in some respects, and the groups that we identified within it are likely to differ from psychiatric and neurological samples in other studies and in clinical practice, with regard to sociodemographic characteristics, illness severity and motivational factors.
Cullen B, Smith DJ, Deary IJ, Evans JJ, Pell JP. The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort. Acta Psychiatr Scand. 2017 Jun;135(6):593-605. doi: 10.1111/acps.12733. Epub 2017 Apr 7.