| Title: | Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 9 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36893272/ |
| DOI: | https://doi.org/10.1073/pnas.2214834120 |
Publication 7908
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Abstract
Human cortical expansion has occurred non-uniformly across the brain. We assessed the genetic architecture of cortical global expansion and regionalization by comparing two sets of genome-wide association studies of 24 cortical regions with and without adjustment for global measures (i.e., total surface area, mean cortical thickness) using a genetically informed parcellation in 32,488 adults. We found 393 and 756 significant loci with and without adjusting for globals, respectively, where 8% and 45% loci were associated with more than one region. Results from analyses without adjustment for globals recovered loci associated with global measures. Genetic factors that contribute to total surface area of the cortex particularly expand anterior/frontal regions, whereas those contributing to thicker cortex predominantly increase dorsal/frontal-parietal thickness. Interactome-based analyses revealed significant genetic overlap of global and dorsolateral prefrontal modules, enriched for neurodevelopmental and immune system pathways. Consideration of global measures is important in understanding the genetic variants underlying cortical morphology.11 Authors
- Carolina Makowski
- Hao Wang
- Anjali Srinivasan
- Anna Qi
- Yuqi Qiu
- Dennis van der Meer
- Oleksandr Frei
- Jingjing Zou
- Peter M. Visscher
- Jian Yang
- Chi-Hua Chen
1 Application
| Application ID | Title |
|---|---|
| 27412 | Boosting the power of GWAS using novel statistical tools |
Enabling scientific discoveries that improve human health