| Title: | Exploring the secrets of super-aging: a UK Biobank study on brain health and cognitive function |
| Journal: | GeroScience |
| Published: | 22 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36947307/ |
| DOI: | https://doi.org/10.1007/s11357-023-00765-x |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651574 |
| Citations: | 4 (4 in last 2 years) as of 8 Aug 2024 |
Publication 7894
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Abstract
Communities across the globe are faced with a rapidly aging society, where age is the main risk factor for cognitive decline and development of Alzheimer's and related diseases. Despite extensive research, there have been no successful treatments yet. A rare group of individuals called "super-agers" have been noted to thrive with their exceptional ability to maintain a healthy brain and normal cognitive function even in old age. Studying their traits, lifestyles, and environments may provide valuable insight. This study used a data-driven approach to identify potential super-agers among 7121 UK Biobank participants and found that these individuals have the highest total brain volume, best cognitive performance, and lowest functional connectivity. The researchers suggest a novel hypothesis that these super-agers possess enhanced neural processing efficiency that increases with age and introduce a definition of the "neural efficiency index." Furthermore, several other types of aging were identified and significant structural-functional differences were observed between them, highlighting the benefit of research efforts in personalized medicine and precision nutrition.</p>
11 Authors
- Brandon S. Klinedinst
- Mihir K. Kharate
- Parvin Mohammadiarvejeh
- Mohammad Fili
- Amy Pollpeter
- Brittany A. Larsen
- Shannin Moody
- Qian Wang
- Karin Allenspach
- Jonathan P. Mochel
- Auriel A. Willette
1 Application
| Application ID | Title |
|---|---|
| 25057 | SIM-BIO-CIS (pronounced Symbiosis) Signalling, Imaging and Metabolic Biobank Composition at Iowa State |
Enabling scientific discoveries that improve human health