| Title: | Discordance in chromosomal and self-reported sex in the UK Biobank: Implications for transgender- and intersex-inclusive data collection |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 24 Apr 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37094118/ |
| DOI: | https://doi.org/10.1073/pnas.2218700120 |
Publication 7863
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Abstract
There is growing need to distinguish between sex and gender. While sex is assigned at birth, gender is socially constructed and may not correspond to one's assigned sex. However, in most research studies, sex or gender is assessed in isolation or the terms are used interchangeably, which has implications for research accuracy and inclusivity. We used data from the UK Biobank to quantify the prevalence of disagreement between chromosomal and self-reported sex and identify potential reasons for discordance. Among approximately 200 individuals with sex discordance, 71% of discordances were potentially explained by the presence of intersex traits or transgender identity. The findings indicate that when describing sex- and/or gender-specific differences in health, researchers may be limited in their ability to draw conclusions regarding specific sex and/or gender health information.6 Authors
- Sarah F. Ackley
- Scott C. Zimmerman
- Jason D. Flatt
- Alicia R. Riley
- Jae Sevelius
- Kate A. Duchowny
1 Application
| Application ID | Title |
|---|---|
| 78748 | Tools for evaluating bias in ADRD research |
Enabling scientific discoveries that improve human health