| Title: | Contraception ends the genetic maintenance of human same-sex sexual behavior |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 15 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37186855/ |
| DOI: | https://doi.org/10.1073/pnas.2303418120 |
Publication 7830
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Abstract
Because human same-sex sexual behavior (SSB) is heritable and leads to fewer offspring, it is puzzling why SSB-associated alleles have not been selectively purged. Current evidence supports the antagonistic pleiotropy hypothesis that SSB-associated alleles benefit individuals exclusively performing opposite-sex sexual behavior by increasing their number of sexual partners and consequently their number of offspring. However, by analyzing the UK Biobank, here, we show that having more sexual partners no longer predicts more offspring since the availability of oral contraceptives in the 1960s and that SSB is now genetically negatively correlated with the number of offspring, suggesting a loss of SSB's genetic maintenance in modern societies.2 Authors
- Siliang Song
- Jianzhi Zhang
1 Application
| Application ID | Title |
|---|---|
| 48678 | Testing the role of positive selection in recent rises of disease incidences |
Enabling scientific discoveries that improve human health