| Title: | Cognitive function in UK adults seropositive for Helicobacter pylori |
| Journal: | PLOS ONE |
| Published: | 7 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37285350/ |
| DOI: | https://doi.org/10.1371/journal.pone.0286731 |
| URL: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0286731&type=printable |
Publication 7803
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Abstract
Associated with gastritis, peptic-ulcer disease, and gastric carcinoma, Helicobacter pylori (H. pylori) also has been associated with decreased cognitive function and dementia. In this study, we used data from the UK Biobank to further examine associations between H. pylori seropositivity and serointensity and performance on several cognitive tasks in adults 40 to 70 years of age (M = 55.3, SD = 8.1). In these analyses, H. pylori seropositivity (i.e., either positive or negative for H. pylori) and serointensity (concentration of antibodies against H. pylori antigens) in adjusted models were associated with worse function on tasks of Numeric memory, Reasoning, and errors on the Pairs matching test but better function on the Tower rearrangement task. Together, these findings suggest that H. pylori seropositivity and serointensity might be associated with worse cognitive function in this age group.6 Authors
- Lance D. Erickson
- David S. White
- Pierce Bassett
- Shawn D. Gale
- Bruce L. Brown
- Dawson Hedges
1 Application
| Application ID | Title |
|---|---|
| 41535 | Associations between air quality, regional brain volumes, cognitive functioning, and neuropsychiatric outcome in middle-aged and older adults: a cross-sectional study |
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