| Title: | Associations of Macronutrients Intake with MRI-Determined Hepatic Fat Content, Hepatic Fibro-inflammation, and NAFLD. |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 8 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37290038/ |
| DOI: | https://doi.org/10.1210/clinem/dgad346 |
Publication 7801
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Abstract
CONTEXT: A healthy lifestyle is the cornerstone of management in non-alcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking. OBJECTIVE: To evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepatic fibro-inflammation, and NAFLD. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, a total of 12,620 UK Biobank participants who completed both the dietary questionnaire and magnetic resonance imaging (MRI) examination were included in this study. MAIN OUTCOMES AND MEASURES: Dietary consumption of macronutrient was self-reported and calculated. MRI-determined hepatic fat content, fibro-inflammation, and NAFLD were estimated. RESULTS: Firstly, we found that saturated fatty acids (SFA) intake was associated with higher hepatic steatosis, fibro-inflammation, and the NAFLD prevalence. In contrast, higher fiber or protein intake was reversely correlated with hepatic steatosis and fibro-inflammation. Interestingly, starch or sugar intake was significantly associated with hepatic fibro-inflammation while monounsaturated fatty acids (MUFA) intake was negatively correlated with hepatic fibro-inflammation. Isocaloric analysis revealed that replacing SFA with sugar, fiber, or protein was significantly associated with a reduction in hepatic steatosis, while replacing starch, sugar, or SFA with protein or MUFA was significantly correlated with a decrease in hepatic fibro-inflammation. CONCLUSION: Overall, our results demonstrate that specific macronutrients are associated with different aspects of NAFLD, and specific dietary compositions should be recommended for distinct NAFLD-risk populations.7 Authors
- Shen Chen
- Juan Pang
- Rong Huang
- Yiran You
- Haoyang Zhang
- Hongliang Xue
- Xu Chen
1 Application
| Application ID | Title |
|---|---|
| 76670 | Nutritional and lifestyle influences on the risk and outcome of different metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes |
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