| Title: | Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure |
| Journal: | Journal of International Medical Research |
| Published: | 20 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37340719/ |
| DOI: | https://doi.org/10.1177/03000605231182881 |
| URL: | https://journals.sagepub.com/doi/pdf/10.1177/03000605231182881 |
Publication 7791
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Abstract
OBJECTIVES: To identify respiratory comorbidities associated with a high risk of developing respiratory failure in subjects with psoriasis. METHODS: This was a cross-sectional analysis of data from subjects enrolled in the UK Biobank cohort. All diagnoses were self-reported. The risk of each respiratory comorbidity was compared by logistic regression models adjusting for age, sex, weight, diabetes mellitus, and smoking history; the risk of comorbid respiratory failure for each pulmonary comorbidity was also compared. RESULTS: Of the 472,782 Caucasian subjects in the database, 3,285 self-reported a diagnosis of psoriasis. More men and smokers reported psoriasis and were older, had higher weight and body mass index, and lower pulmonary function than non-psoriatic subjects. Those with psoriasis were at significantly higher risk for multiple pulmonary comorbidities compared to those without psoriasis. Furthermore, those with psoriasis had a higher risk for respiratory failure accompanied by asthma and airflow limitation than non-psoriatic subjects. CONCLUSIONS: Subjects with psoriasis and pulmonary comorbidities, such as asthma and airflow limitation, are at increased risk for respiratory failure. Common immunopathological links implicating a 'skin-lung axis' may underlie psoriasis and pulmonary comorbidities.4 Authors
- Kazuya Tanimura
- Seyed Mehdi Nouraie
- Divay Chandra
- Toru Nyunoya
1 Application
| Application ID | Title |
|---|---|
| 60327 | Role of Caspase 12 in respiratory diseases among people of African decent |
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