| Title: | Inflammatory Bowel Disease With Chronic Kidney Disease and Acute Kidney Injury |
| Journal: | American Journal of Preventive Medicine |
| Published: | 10 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37572855/ |
| DOI: | https://doi.org/10.1016/j.amepre.2023.08.008 |
Publication 7698
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Abstract
INTRODUCTION: It remains unclear whether inflammatory bowel disease is associated with long-term risk of chronic kidney disease (CKD) and acute kidney injury (AKI) in the general population.</p>
METHODS: A total of 417,302 participants, including 2,940 patients with ulcerative colitis and 1,261 patients with Crohn's disease, without previous CKD and AKI at baseline (2006-2010) from the UK Biobank were included. The study outcomes included incident CKD and AKI, ascertained by self-report data and data linkage with primary care, hospital admissions, and death registry records. Analysis was conducted in 2022.</p>
RESULTS: During a median follow-up of 12.5 years, 13,564 and 14,331 participants developed CKD and AKI, respectively. Compared with the hazard ratio for non-inflammatory bowel diseases, the hazard ratios for CKD and AKI related to inflammatory bowel diseases were 1.57 (95% CI=1.37, 1.79) and 1.96 (95% CI=1.74, 2.20) after adjustments for age, sex, and race and were 1.32 (95% CI=1.15, 1.51) and 1.70 (95% CI=1.51, 1.91) after further adjustments for biological, behavioral, and socioeconomic factors in addition to mental health and self-rated health. Similar results were found for patients with Crohn's disease (adjusted hazard ratio=1.38 (95% CI=1.09, 1.75) for CKD and 1.62 [95% CI=1.30, 2.02] for AKI) and those with ulcerative colitis (adjusted hazard ratio=1.29 (95% CI=1.09, 1.51) for CKD and 1.71 [95% CI=1.49, 1.97] for AKI) in the fully adjusted models. Genetic risks of kidney diseases did not significantly affect the association of inflammatory bowel disease with incident CKD and AKI (both p-interactions>0.05). The association between inflammatory bowel disease and the risk of incident CKD (p-interaction=0.010) and AKI (p-interaction<0.001) were stronger in younger participants than in older participants.</p>
CONCLUSIONS: Inflammatory bowel disease was associated with higher risks for CKD and AKI, independent of genetic risks of kidney diseases.</p>
9 Authors
- Mengyi Liu
- Yanjun Zhang
- Ziliang Ye
- Sisi Yang
- Chun Zhou
- Panpan He
- Yuanyuan Zhang
- Fan Fan Hou
- Xianhui Qin
1 Application
| Application ID | Title |
|---|---|
| 73201 | Identification of residual risks of non-infectious chronic diseases |
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