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Genetic association analysis was performed in SNPTEST with the expected method using an additive genetic model adjusted for age, sex, 10 principal components of ancestry and genotyping array. Genome-wide association analysis was performed separately for continuous chronotype and extreme chronotype with a genome-wide significance threshold of 5x10-8.
Lane JM, Rutter M, Anderson S, Saxena R et al. Genome-wide association study reveals ten loci associated with chronotype in the UKBiobank. Nat Commun. 2016 Mar 9;7:10889. doi: 10.1038/ncomms10889. PubMed PMID: 26955885; PubMed Central PMCID: PMC4786869.