Title: | Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection |
Journal: | Nat Genet |
Published: | 1 Oct 2017 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28892061/ |
DOI: | https://doi.org/10.1038/ng.3954 |
Title: | Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection |
Journal: | Nat Genet |
Published: | 1 Oct 2017 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28892061/ |
DOI: | https://doi.org/10.1038/ng.3954 |
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
In this study we determined that SNPs with low level of LD (LLD) have significantly larger per-SNP heritability. Roughly half of the LLD signal can be explained by functional annotations that are negatively correlated with LLD, such as DNase I hypersensitivity sites (DHS) and histone marks. The remaining signal is driven by annotations related on negative selection, highlighting the effect of negative on all polygenic complex traits.
Steven Gazal, Hilary K. Finucane, Po-Ru Loh, Pier Francesco Palamara, Xuanyao Liu, Armin Schoech, Brendan Bulik-Sullivan, Benjamin M Neale, Alexander Gusev, Alkes L. Price1. Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection Nature Genetics volume 49, pages 1421 1427 (2017) doi:10.1038/ng.3954
Application ID | Title |
---|---|
16549 | Components of heritability in a UK Biobank cohort |
Enabling scientific discoveries that improve human health