| Title: | Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank. |
| Journal: | Diabetes Care |
| Published: | 2 Dec 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34857534/ |
| DOI: | https://doi.org/10.2337/dc21-1512 |
| Citations: | 111 (102 in last 2 years) as of 8 Aug 2024 |
Publication 7240
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Abstract
OBJECTIVE: To evaluate the association of a healthy lifestyle, involving seven low-risk factors mentioned in diabetes management guidelines (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, adequate sleep duration, and appropriate social connection), with all-cause and cause-specific mortality among individuals with type 2 diabetes.</p>
RESEARCH DESIGN AND METHODS: This study included 13,366 participants with baseline type 2 diabetes from the UK Biobank free of cardiovascular disease (CVD) and cancer. Lifestyle information was collected through a baseline questionnaire.</p>
RESULTS: During a median follow-up of 11.7 years, 1,561 deaths were documented, with 625 from cancer, 370 from CVD, 115 from respiratory disease, 81 from digestive disease, and 74 from neurodegenerative disease. In multivariate-adjusted model, each lifestyle factor was significantly associated with all-cause mortality, and hazard ratios associated with the lifestyle score (scoring 6-7 vs. 0-2 unless specified) were 0.42 (95% CI 0.34, 0.52) for all-cause mortality, 0.57 (0.41, 0.80) for cancer mortality, 0.35 (0.22, 0.56) for CVD mortality, 0.26 (0.10, 0.63) for respiratory mortality, and 0.28 (0.14, 0.53) for digestive mortality (scoring 5-7 vs. 0-2). In the population-attributable risk analysis, 29.4% (95% CI 17.9%, 40.9%) of deaths were attributable to a poor lifestyle (scoring 0-5). The association between a healthy lifestyle and all-cause mortality was consistent, irrespective of factors reflecting diabetes severity (diabetes duration, glycemic control, diabetes-related microvascular disease, and diabetes medication).</p>
CONCLUSIONS: A healthy lifestyle was associated with a lower risk of all-cause mortality and mortality due to CVD, cancer, respiratory disease, and digestive disease among individuals with type 2 diabetes.</p>
11 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Cause of Death
- Diabetes Mellitus, Type 2
- Healthy Lifestyle
- Humans
- Life Style
- Neurodegenerative Diseases
- Prospective Studies
- Risk Factors
- United Kingdom
9 Authors
- Han Han
- Yaying Cao
- Chengwu Feng
- Yan Zheng
- Klodian Dhana
- Shu Zhu
- Cong Shang
- Changzheng Yuan
- Geng Zong
1 Application
| Application ID | Title |
|---|---|
| 55005 | Common risk factors and mechanisms in cardiometabolic diseases and neurodegenerative diseases |
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