| Title: | Protein Nutritional Status and Frailty: A Mendelian Randomization Study |
| Journal: | Journal of Nutrition |
| Published: | 23 Nov 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34601600/ |
| DOI: | https://doi.org/10.1093/jn/nxab348 |
| URL: | http://academic.oup.com/jn/advance-article-pdf/doi/10.1093/jn/nxab348/40501285/nxab348.pdf |
| Citations: | 5 (5 in last 2 years) as of 8 Aug 2024 |
Publication 5618
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Abstract
BACKGROUND: Observational studies have suggested that better protein nutritional status may contribute to prevention of frailty.</p>
OBJECTIVE: We sought to examine this hypothesis using a Mendelian randomization (MR) analysis.</p>
METHODS: We conducted a two-sample MR study using GWAS summary statistics data of the UK Biobank. We applied genetically predicted serum albumin as a primary exposure measure and serum total protein as a secondary exposure measure. The outcome measure was the Rockwood frailty index (FI) based on 49 deficits from 356,432 individuals (53.3% of them were women, with a mean ± SD age of 56.7 ± 8.0 y. The association between serum protein measures and FI was mainly analyzed by use of the inverse variance weighted method.</p>
RESULTS: A genetically predicted serum albumin concentration was not statistically significantly associated with FI in the full sample. However, in women, we observed a preventive association between genetically predicted serum albumin and FI (β = -0.172 per g/L; 95% CI: -0.336, -0.007; P = 0.041). In the full sample, genetically predicted serum total protein was inversely associated with FI (β: -0.153 per g/L; 95% CI: -0.251, -0.056; P = 0.002). In both women and men, higher serum total protein was significantly inversely associated with FI; regression coefficients were -0.148 per g/L (95% CI: -0.287, -0.009; P = 0.037) for women, -0.154 per g/L (95% CI: -0.290, -0.018; P = 0.027) for men.</p>
CONCLUSIONS: The present MR study implies that better protein nutritional status modestly contributes to reducing the risk of frailty.</p>
8 Keywords
- Female
- Frailty
- Genome-Wide Association Study
- Humans
- Male
- Mendelian Randomization Analysis
- Nutritional Status
- Polymorphism, Single Nucleotide
4 Authors
- Yasutake Tomata
- Yunzhang Wang
- Sara Hägg
- Juulia Jylhävä
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