| Title: | Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort |
| Journal: | Psychological Medicine |
| Published: | 21 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33081855/ |
| DOI: | https://doi.org/10.1017/s0033291720003657 |
| URL: | https://kclpure.kcl.ac.uk/portal/en/publications/753b2c8e-c599-47fc-891f-f00cadadcac4 |
| Citations: | 36 (21 in last 2 years) as of 8 Aug 2024 |
Publication 5616
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Abstract
BACKGROUND: A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank.</p>
METHODS: We assessed prospective associations between vitamin D status at the baseline assessment (2006-2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank.</p>
RESULTS: Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07-1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13-1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00-1.23; deficiency: aOR = 1.30, 95% CI 1.13-1.50).</p>
CONCLUSIONS: The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health.</p>
8 Keywords
- Adult
- Biological Specimen Banks
- Cohort Studies
- Humans
- Middle Aged
- United Kingdom
- Vitamin D
- Vitamin D Deficiency
7 Authors
- Amy Ronaldson
- Jorge Arias de la Torre
- Fiona Gaughran
- Ioannis Bakolis
- Stephani L. Hatch
- Matthew Hotopf
- Alexandru Dregan
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