| Title: | Polygenic risk score, healthy lifestyles, and risk of incident depression |
| Journal: | Translational Psychiatry |
| Published: | 29 Mar 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33782378/ |
| DOI: | https://doi.org/10.1038/s41398-021-01306-w |
| URL: | https://www.nature.com/articles/s41398-021-01306-w.pdf |
Publication 5573
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Abstract
Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of genetic risk. Data were obtained from the UK Biobank and consisted of 339,767 participants (37-73 years old) without depression between 2006 and 2010. Genetic risk was categorized as low, intermediate, or high according to polygenic risk score for depression. A combination of healthy lifestyles factors - including no current smoking, regular physical activity, a healthy diet, moderate alcohol intake and a body mass index <30 kg/m2 - was categorized into favorable, intermediate, and unfavorable lifestyles. The risk of depression was 22% higher among those at high genetic risk compared with those at low genetic risk (HR = 1.22, 95% CI: 1.14-1.30). Participants with high genetic risk and unfavorable lifestyle had a more than two-fold risk of incident depression compared with low genetic risk and favorable lifestyle (HR = 2.18, 95% CI: 1.84-2.58). There was no significant interaction between genetic risk and lifestyle factors (P for interaction = 0.69). Among participants at high genetic risk, a favorable lifestyle was associated with nearly 50% lower relative risk of depression than an unfavorable lifestyle (HR = 0.51, 95% CI: 0.43-0.60). We concluded that genetic and lifestyle factors were independently associated with risk of incident depression. Adherence to healthy lifestyles may lower the risk of depression regardless of genetic risk.</p>
7 Authors
- Zhi Cao
- Hongxi Yang
- Yixuan Ye
- Yuan Zhang
- Shu Li
- Hongyu Zhao
- Yaogang Wang
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