| Title: | Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease |
| Journal: | Communications Biology |
| Published: | 27 Mar 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30937401/ |
| DOI: | https://doi.org/10.1038/s42003-019-0361-2 |
| Citations: | 41 (15 in last 2 years) as of 8 Aug 2024 |
Publication 5367
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Abstract
There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.</p>
17 Authors
- Eirini Marouli
- M. Fabiola Del Greco
- Christina M. Astley
- Jian Yang
- Shafqat Ahmad
- Sonja I. Berndt
- Mark J. Caulfield
- Evangelos Evangelou
- Barbara McKnight
- Carolina Medina-Gomez
- Jana V. van Vliet-Ostaptchouk
- Helen R. Warren
- Zhihong Zhu
- Joel N. Hirschhorn
- Ruth J. F. Loos
- Zoltan Kutalik
- Panos Deloukas
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