| Title: | Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology |
| Journal: | Nature Communications |
| Published: | 5 Feb 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33547301/ |
| DOI: | https://doi.org/10.1038/s41467-020-20870-1 |
| URL: | https://www.nature.com/articles/s41467-020-20870-1.pdf |
| Citations: | 81 (51 in last 2 years) as of 8 Aug 2024 |
Publication 5050
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations.19 Keywords
- Alanine Transaminase
- Alkaline Phosphatase
- Aspartate Aminotransferases
- Biological Specimen Banks
- Endothelial Cells
- Gene Expression Regulation
- Genome, Human
- Genome-Wide Association Study
- Hepatocytes
- Humans
- Japan
- Killer Cells, Natural
- Kupffer Cells
- Liver
- Liver Diseases
- Quantitative Trait Loci
- Quantitative Trait, Heritable
- Single-Cell Analysis
- United Kingdom
11 Authors
- Vincent L. Chen
- Xiaomeng Du
- Yanhua Chen
- Annapurna Kuppa
- Samuel K. Handelman
- Rishel B. Vohnoutka
- Patricia A. Peyser
- Nicholette D. Palmer
- Lawrence F. Bielak
- Brian Halligan
- Elizabeth K. Speliotes
Enabling scientific discoveries that improve human health