| Title: | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| Journal: | Nature Communications |
| Published: | 8 May 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29739929/ |
| DOI: | https://doi.org/10.1038/s41467-018-04086-y |
| URL: | https://kclpure.kcl.ac.uk/ws/files/96808782/Genome_wide_association_study_VISCONTI_Published8May2018_GOLD_VoR_CC_BY_.pdf |
| Citations: | 92 (18 in last 2 years) as of 8 Aug 2024 |
Publication 5032
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Abstract
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.</p>
27 Keywords
- Adult
- Aged
- Carrier Proteins
- Chromosome Mapping
- Female
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Hair Color
- Humans
- Male
- Melanoma
- Middle Aged
- Neoplasm Proteins
- Neoplasms, Radiation-Induced
- Phenotype
- Polymorphism, Single Nucleotide
- Prospective Studies
- Radiation Exposure
- Receptors, Aryl Hydrocarbon
- Risk Factors
- Sex Factors
- Skin Neoplasms
- Sunburn
- Suntan
- United Kingdom
- White People
22 Authors
- Alessia Visconti
- David L. Duffy
- Fan Liu
- Gu Zhu
- Wenting Wu
- Yan Chen
- Pirro G. Hysi
- Changqing Zeng
- Marianna Sanna
- Mark M. Iles
- Peter A. Kanetsky
- Florence Demenais
- Merel A. Hamer
- Andre G. Uitterlinden
- M. Arfan Ikram
- Tamar Nijsten
- Nicholas G. Martin
- Manfred Kayser
- Tim D. Spector
- Jiali Han
- Veronique Bataille
- Mario Falchi
Enabling scientific discoveries that improve human health