| Title: | Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders |
| Journal: | Annals of Neurology |
| Published: | 5 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32951248/ |
| DOI: | https://doi.org/10.1002/ana.25910 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048405 |
Publication 4936
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Abstract
Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD-GRS score was associated with shorter sleep (b = -0.014, 95% confidence interval [CI] = -0.022 to -0.006), especially in those aged 55+. Using AD-GRS as an instrumental variable for AD diagnosis, incipient AD reduced sleep duration by 1.87 hours (95% CI = 0.96, 2.78). Short sleep duration might be an early marker of AD. ANN NEUROL 2021;89:177-181.</p>
5 Authors
- Yue Leng
- Sarah F. Ackley
- Maria M. Glymour
- Kristine Yaffe
- Willa D. Brenowitz
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