| Title: | Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study |
| Journal: | Neurology |
| Published: | 9 Jan 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30626649/ |
| DOI: | https://doi.org/10.1212/wnl.0000000000006879 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093082 |
Publication 4176
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Abstract
OBJECTIVE: To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume.</p>
METHODS: We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced with structural MRI.</p>
RESULTS: After adjustment for a range of covariates, higher levels of all obesity measures were related to lower gray matter volume: BMI per 1 SD (β coefficient -4,113, 95% confidence interval [CI] -4,862 to -3,364), WHR (β coefficient -4,272, 95% CI -5,280 to -3,264), and fat mass (β coefficient -4,590, 95% CI -5,386 to -3,793). The combination of overall obesity (BMI ≥30 kg/m2) and central obesity (WHR >0.85 for women, >0.90 for men) was associated with the lowest gray matter compared with that in lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes, including caudate, putamen, pallidum, and nucleus accumbens. No associations between obesity and white matter were apparent.</p>
CONCLUSION: The combination of heightened BMI and WHR may be an important risk factor for gray matter atrophy.</p>
21 Keywords
- Adult
- Aged
- Atrophy
- Body Mass Index
- Brain
- Caudate Nucleus
- Cross-Sectional Studies
- Female
- Globus Pallidus
- Gray Matter
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nucleus Accumbens
- Obesity
- Obesity, Abdominal
- Organ Size
- Putamen
- United Kingdom
- Waist-Hip Ratio
2 Authors
- Mark Hamer
- G David Batty
1 Application
| Application ID | Title |
|---|---|
| 23476 | Physical activity, adiposity and brain health |
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