| Title: | Cancer and Cardiovascular Risk in Women With Hypertensive Disorders of Pregnancy Carrying a Common IGF1R Variant |
| Journal: | Mayo Clinic Proceedings |
| Published: | 6 Nov 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33168159/ |
| DOI: | https://doi.org/10.1016/j.mayocp.2020.03.037 |
| URL: | http://www.mayoclinicproceedings.org/article/S0025619620306522/pdf |
Publication 3763
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
OBJECTIVE: To evaluate the impact of insulin-like growth factor 1 receptor variant rs2016347 on the risk for breast and nonbreast cancers and cardiovascular disease in women with a history of hypertensive disorders of pregnancy (HDP).</p>
PATIENTS AND METHODS: This retrospective cohort study included all parous women in the UK Biobank with prior rs2016347 genotyping (N=204,155), with enrollment taking place from March 2006 to July 2010. History of HDP was self-reported, and outcomes included breast and all nonbreast cancers, hospital diagnoses of hypertension and cardiovascular disease, and direct blood pressure measurements.</p>
RESULTS: Women with previous HDP had a higher risk for future hypertension and cardiovascular diagnoses, increased blood pressures, and lower risk for breast cancer compared with women without HDP, consistent with prior studies. Hazard ratios for all nonbreast cancers were unchanged. However, when taking genotype into account, HDP-positive women carrying at least 1 thymine (T) allele of rs2016347 had a lower risk for nonbreast cancer (hazard ratio, 0.59; 95% CI, 0.37 to 0.92; P=.02) and lower systolic blood pressure (-2.08±0.98 mm Hg; P=.03) compared with women with the guanine/guanine (GG) genotype with positive evidence of interaction (HDP:T allele) for both outcomes; P=.04 and P=.03, respectively.</p>
CONCLUSION: Women who experience HDP and carry a T allele of rs2016347 have 41% lower risk for developing nonbreast cancer and a lower systolic blood pressure of 2.08 mm Hg when compared with those with the GG genotype, suggesting a possible role of the insulin-like growth factor 1 axis for both cardiovascular and cancer risk in women with HDP.</p>
15 Keywords
- Adult
- Blood Pressure Determination
- Cohort Studies
- Female
- Heart Disease Risk Factors
- Humans
- Hypertension, Pregnancy-Induced
- Neoplasms
- Polymorphism, Single Nucleotide
- Pregnancy
- Pregnancy Complications, Cardiovascular
- Receptor, IGF Type 1
- Retrospective Studies
- Risk Assessment
- United Kingdom
4 Authors
- Mark J Powell
- Suzanne M Dufault
- Erica P Gunderson
- Christopher C Benz
1 Application
| Application ID | Title |
|---|---|
| 37368 | Future risk of cancer and cardiovascular disease in women who experience a hypertensive disorder of pregnancy, and its modification by a common, functional, IGF1R variant |
Enabling scientific discoveries that improve human health