| Title: | Associations of BMI and Serum Urate with Developing Dementia: A Prospective Cohort Study. |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 12 Sep 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32918088/ |
| DOI: | https://doi.org/10.1210/clinem/dgaa638 |
| URL: | https://academic.oup.com/jcem/article-pdf/105/12/e4688/41829155/dgaa638.pdf |
Publication 3727
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Recent studies have suggested that a higher body mass index (BMI) and serum urate levels were associated with a lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.OBJECTIVES: To investigate the independent associations of BMI and urate, as well as their interaction with the risk of developing dementia.
DESIGN AND SETTINGS: We analyzed a cohort of 502 528 individuals derived from the UK Biobank that included people aged 37-73 years for whom BMI and urate were recorded between 2006 and 2010. Dementia was ascertained at follow-up using electronic health records.
RESULTS: During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were underweight had an increased risk of dementia (hazard ratio [HR] = 1.91, 95% confidence interval [CI]: 1.24-2.97) compared with people of a healthy weight. However, the risk of dementia continued to fall as weight increased, as those who were overweight and obese were 19% (HR = 0.81, 95%: 0.73-0.90) and 22% (HR = 0.78, 95% CI: 0.68-0.88) were less likely to develop dementia than people of a healthy weight. People in the highest quintile of urate were also associated with a 25% (HR = 0.75, 95% CI: 0.64-0.87) reduction in the risk of developing dementia compared with those who were in the lowest quintile. There was a significant multiplicative interaction between BMI and urate in relation to dementia (P for interaction = 0.004), and obesity strengthens the protective effect of serum urate on the risk of dementia.
CONCLUSION: Both BMI and urate are independent predictors of dementia, and there are inverse monotonic and dose-response associations of BMI and urate with dementia.
7 Authors
- Zhi Cao
- Chenjie Xu
- Hongxi Yang
- Shu Li
- Fusheng Xu
- Yuan Zhang
- Yaogang Wang
1 Application
| Application ID | Title |
|---|---|
| 45676 | The joint effects of genetic, lifestyle and environmental risk factors on common diseases and multimorbidity. |
Enabling scientific discoveries that improve human health