| Title: | Evidence of horizontal indirect genetic effects in humans |
| Journal: | Nature Human Behaviour |
| Published: | 14 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33318663/ |
| DOI: | https://doi.org/10.1038/s41562-020-00991-9 |
| URL: | http://hdl.handle.net/20.500.11820/3db8d8f4-1850-46cc-870d-9546cdb183b6 |
Publication 3617
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Abstract
Indirect genetic effects, the effects of the genotype of one individual on the phenotype of other individuals, are environmental factors associated with human disease and complex trait variation that could help to expand our understanding of the environment linked to complex traits. Here, we study indirect genetic effects in 80,889 human couples of European ancestry for 105 complex traits. Using a linear mixed model approach, we estimate partner indirect heritability and find evidence of partner heritability on ~50% of the analysed traits. Follow-up analysis suggests that in at least ~25% of these traits, the partner heritability is consistent with the existence of indirect genetic effects including a wide variety of traits such as dietary traits, mental health and disease. This shows that the environment linked to complex traits is partially explained by the genotype of other individuals and motivates the need to find new ways of studying the environment.4 Authors
- Charley Xia
- Oriol Canela-Xandri
- Konrad Rawlik
- Albert Tenesa
1 Application
| Application ID | Title |
|---|---|
| 788 | Heritability of disease frequency |
Enabling scientific discoveries that improve human health