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Abstract
First, we performed a Genome-Wide Association Study (GWAS) on an anhedonia phenotype that identified 11 regions of the genome. The phenotype was based on the question of how many days in the past two weeks the respondent didn't get pleasure form things they usually enjoyed with the responses were grouped into the proportion of days in the last two weeks. We then correlated the summary statistics of the GWAS with GWAS summary statistics for psychiatric pathologies. The final thing we did was created polygenic risk scores and found that genetic loading for anhedonia associated with poorer brain white matter integrity, smaller total grey matter volume, and smaller volumes of brain regions linked to reward and pleasure processing, including orbito-frontal cortex.