| Title: | Association Between Population Density and Genetic Risk for Schizophrenia |
| Journal: | JAMA Psychiatry |
| Published: | 1 Sep 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29936532/ |
| DOI: | https://doi.org/10.1001/jamapsychiatry.2018.1581 |
Publication 3202
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Abstract
We showed that the genetic risk for schizophrenia was not randomly distributed across the UK (England, Wales and Scotland) and in particular that risk alleles were more common in urban/densely populated areas, consistent with the reporter higher rates of schizophrenia observed in urban area. We identified a handful of genetic variants associated with living in a populated environment that do not allow do predict much at an individual level. We found that the genetic risk for schizophrenia likely causes people to live in more densely populated area, though it does not preclude anything about the reverse relationship (which we could not test). Our work raises important questions about the selection of certain (individuals with) risk alleles by the urban environment, or on the contrary about the possible causal effect of city living on psychiatric risk. Note that those hypotheses are not mutually exclusive.1 Author
- Colodro-Conde L et al.
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
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