| Title: | Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis |
| Journal: | Nature Genetics |
| Published: | 4 Sep 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28869591/ |
| DOI: | https://doi.org/10.1038/ng.3949 |
| URL: | https://europepmc.org/articles/pmc5621629?pdf=render |
| Citations: | 400 (82 in last 2 years) as of 8 Aug 2024 |
Publication 3142
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Abstract
David Evans, Brent Richards and colleagues carried out a genome-wide association study in 142,487 individuals from the UK Biobank and identified 153 new loci associated with heel bone mineral density. They also conducted in vivo studies that implicated GPC6 and several other genes in osteoporosis.22 Keywords
- Animals
- Bone Density
- Calcaneus
- Disease Models, Animal
- Female
- Femur
- Gene Expression Profiling
- Genome-Wide Association Study
- Glypicans
- Growth Disorders
- Humans
- Male
- Mice
- Mice, Knockout
- Molecular Sequence Annotation
- Osteoblasts
- Osteochondrodysplasias
- Osteoclasts
- Osteocytes
- Osteoporosis
- Phenotype
- Polymorphism, Single Nucleotide
38 Authors
- John P Kemp
- John A Morris
- Carolina Medina-Gomez
- Vincenzo Forgetta
- Nicole M Warrington
- Scott E Youlten
- Jie Zheng
- Celia L Gregson
- Elin Grundberg
- Katerina Trajanoska
- John G Logan
- Andrea S Pollard
- Penny C Sparkes
- Elena J Ghirardello
- Rebecca Allen
- Victoria D Leitch
- Natalie C Butterfield
- Davide Komla-Ebri
- Anne-Tounsia Adoum
- Katharine F Curry
- Jacqueline K White
- Fiona Kussy
- Keelin M Greenlaw
- Changjiang Xu
- Nicholas C Harvey
- Cyrus Cooper
- David J Adams
- Celia M T Greenwood
- Matthew T Maurano
- Stephen Kaptoge
- Fernando Rivadeneira
- Jonathan H Tobias
- Peter I Croucher
- Cheryl L Ackert-Bicknell
- J H Duncan Bassett
- Graham R Williams
- J Brent Richards
- David M Evans
1 Application
| Application ID | Title |
|---|---|
| 12703 | Investigating the Genetic Architecture Underlying the Developmental Origins of Health and Disease |
Enabling scientific discoveries that improve human health