| Title: | Urinary Sodium Excretion, Blood Pressure, and Risk of Future Cardiovascular Disease and Mortality in Subjects Without Prior Cardiovascular Disease |
| Journal: | Hypertension |
| Published: | 1 Jun 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31067194/ |
| DOI: | https://doi.org/10.1161/HYPERTENSIONAHA.119.12726 |
Publication 2845
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Abstract
High blood pressure is a risk factor for cardiovascular disease. Increased urinary sodium excretion, representing dietary salt intake, has been linked to higher blood pressure. Perhaps surprising, low sodium intake has been associated with increased risk of death observational studies, but this might be due to the issue that patients with major health issues often consume less salt, either due to poor appetite or as they are following medical advice to reduce salt intake.To try and work out if salt intake is linked to blood pressure independent of this confounding issue and longer-term outcomes, we used data from over 300,000 UK Biobank participants without pre-existing cardiovascular disease, diabetes or high blood pressure. Overall there was a clear relationship between increasing salt intake and higher blood pressure. During average follow-up of approximately 7 years there were 11932 deaths (1125 cardiovascular deaths) with 10717 nonfatal cardiovascular events. There was no relationship between salt intake and these outcomes. even after more adjustment for existing health conditions.
Therefore, whilst it is clear that higher salt intake is associated with higher blood pressure in healthy people, it is less clear that this is linked to future cardiovascular events. It might be that the follow up was not long enough to see a link, or that salt intake is less clearly linked to mortality and cardiovascular disease than previously thought.
1 Author
- Welsh CE et al.
1 Application
| Application ID | |
|---|---|
| 9310 | Associations of blood biomarkers with cardiovascular disease and related cardiometabolic outcomes and risk prediction in the clinical setting |
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