| Title: | Women's reproductive factors and incident cardiovascular disease in the UK Biobank |
| Journal: | Heart |
| Published: | 1 Jul 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29335253/ |
| DOI: | https://doi.org/10.1136/heartjnl-2017-312289 |
Publication 2788
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Abstract
Women s reproductive factors and CVDThe UKB run-ID is UKB_9526
Reproduction and pregnancy-related factors may have an adverse effect on a woman s future risk of cardiovascular disease (CVD). Findings in previous studies have, however, been mixed, leading to an inconclusive evidence base. We therefore assessed the relationship between reproductive factors and incident CVD in the UK Biobank. We found that early menarche, early menopause, earlier age at first birth, and a history of miscarriage, stillbirth or hysterectomy, were each associated with a higher risk of CVD in later life, after controlling for key cardiovascular risk factors. Women who had given birth to more children also had higher subsequent CVD risk, but this is unlikely to have been due to a biological cause, as some have hypothesised, because a similar effect was found when analysing the number of children fathered by men.
1 Author
- Peters SA et al.
1 Application
| Application ID | Title |
|---|---|
| 2495 | Sex differences in the association between major and modifiable risk factors with cardiovascular disease |
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