| Title: | Indicators of mental disorders in UK Biobank-A comparison of approaches |
| Journal: | Int J Methods Psychiatr Res |
| Published: | 1 Sep 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31397039/ |
| DOI: | https://doi.org/10.1002/mpr.1796 |
Publication 2709
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Our study discusses the mental health data from UK Biobank and how it could be used. It's a complex picture because of multiple indicators that a participant may have a mental disorder - including self-report ("have you ever been diagnosed with..."), questionnaires with self-report checklists of symptoms, prescription data and hospital discharge.Taking the example of depression, 33,000 people answering the mental health questionnaire report ever having a diagnosis of depression and 37,000 have a lifetime diagnosis of on a diagnostic symptom checklist, but these indicators only agree in 20,000. Not surprisingly, much smaller numbers had received a hospital diagnosis, at around 3,000, because few people are admitted to hospital for their depression. There is no "correct" indicator - all will have advantages and disadvantages. We suggest that the decision of which indicators to use, and how to combine, will depend on the aims of the study as trade-offs exist between sensitivity and specificity. However, all should be aware that the results of genetic or biomarker analyses may change according to how the researchers cut the cake - so the responsibility is on researchers to know the data and openly report their methods.
13 Keywords
- Adult
- Cohort Studies
- Databases, Factual
- Datasets as Topic
- Female
- Humans
- Male
- Medical Records Systems, Computerized
- Mental Disorders
- Middle Aged
- Outcome Assessment, Health Care
- Self Report
- United Kingdom
1 Author
- Davis KAS et al.
1 Application
| Application ID | Title |
|---|---|
| 16577 | Investigations of the genetic overlap between internalising psychiatric disorders and co-morbid physical health disorders. |
Enabling scientific discoveries that improve human health