| Title: | Indicators of mental disorders in UK Biobank-A comparison of approaches |
| Journal: | Int J Methods Psychiatr Res |
| Published: | 1 Sep 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31397039/ |
| DOI: | https://doi.org/10.1002/mpr.1796 |
Publication 2709
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Abstract
Our study discusses the mental health data from UK Biobank and how it could be used. It's a complex picture because of multiple indicators that a participant may have a mental disorder - including self-report ("have you ever been diagnosed with..."), questionnaires with self-report checklists of symptoms, prescription data and hospital discharge.Taking the example of depression, 33,000 people answering the mental health questionnaire report ever having a diagnosis of depression and 37,000 have a lifetime diagnosis of on a diagnostic symptom checklist, but these indicators only agree in 20,000. Not surprisingly, much smaller numbers had received a hospital diagnosis, at around 3,000, because few people are admitted to hospital for their depression. There is no "correct" indicator - all will have advantages and disadvantages. We suggest that the decision of which indicators to use, and how to combine, will depend on the aims of the study as trade-offs exist between sensitivity and specificity. However, all should be aware that the results of genetic or biomarker analyses may change according to how the researchers cut the cake - so the responsibility is on researchers to know the data and openly report their methods.
1 Author
- Davis KAS et al.
1 Application
| Application ID | Title |
|---|---|
| 16577 | Investigations of the genetic overlap between internalising psychiatric disorders and co-morbid physical health disorders. |
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