| Title: | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
| Journal: | Nature Communications |
| Published: | 24 Jun 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31235808/ |
| DOI: | https://doi.org/10.1038/s41467-019-10630-1 |
| URL: | https://www.nature.com/articles/s41467-019-10630-1.pdf |
| Citations: | 221 (109 in last 2 years) as of 8 Aug 2024 |
Publication 2654
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Abstract
Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.</p>
38 Authors
- Dmitry Shungin
- Simon Haworth
- Kimon Divaris
- Cary S. Agler
- Yoichiro Kamatani
- Myoung Keun Lee
- Kelsey Grinde
- George Hindy
- Viivi Alaraudanjoki
- Paula Pesonen
- Alexander Teumer
- Birte Holtfreter
- Saori Sakaue
- Jun Hirata
- Yau-Hua Yu
- Paul M. Ridker
- Franco Giulianini
- Daniel I. Chasman
- Patrik K. E. Magnusson
- Takeaki Sudo
- Yukinori Okada
- Uwe Völker
- Thomas Kocher
- Vuokko Anttonen
- Marja-Liisa Laitala
- Marju Orho-Melander
- Tamar Sofer
- John R. Shaffer
- Alexandre Vieira
- Mary L. Marazita
- Michiaki Kubo
- Yasushi Furuichi
- Kari E. North
- Steve Offenbacher
- Erik Ingelsson
- Paul W. Franks
- Nicholas J. Timpson
- Ingegerd Johansson
1 Application
| Application ID | Title |
|---|---|
| 40644 | Investigating aetiology, associations and causality in diseases of the head and neck |
Enabling scientific discoveries that improve human health