| Title: | Type 2 diabetes mellitus and risk of incident peptic ulcer disease: a large-scale prospective cohort study |
| Journal: | Journal of Diabetes & Metabolic Disorders |
| Published: | 16 Oct 2026 |
| DOI: | https://doi.org/10.1007/s40200-026-02106-z |
Publication 21501
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Abstract
PurposeProspective evidence on the association between type 2 diabetes mellitus (T2DM) and incident peptic ulcer disease (PUD) remains limited, particularly after accounting for comorbidities and medications related to ulcer risk. We examined this association in the UK Biobank.MethodsWe analysed 344,612 participants, including 13,193 with T2DM at baseline, during up to 17.7 years of follow-up. Multivariable Cox proportional hazards models estimated associations of T2DM with incident PUD, gastric ulcer (GU), and duodenal ulcer (DU).ResultsParticipants with T2DM had a higher cumulative incidence of PUD (log-rank P < 0.001). In the fully adjusted model, T2DM was associated with higher risks of PUD (hazard ratio [HR] 1.40, 95% confidence interval [CI] 1.27-1.54), GU (HR 1.34, 95% CI 1.19-1.51), and DU (HR 1.56, 95% CI 1.34-1.82). There was no evidence of interaction by regular pain medication use (P for interaction = 0.473). The associations were similar in three sensitivity analyses.ConclusionBaseline T2DM was associated with a higher risk of incident PUD and its anatomical subtypes. Residual confounding, selection and detection biases, and the lack of systematic Helicobacter pylori data preclude causal interpretation.</p>
5 Authors
- Zhiyu Wu
- He Lu
- Xingyan Zhou
- Ya Zheng
- Rui Ji
1 Application
| Application ID | Title |
|---|---|
| 456996 | Impact of Modifiable and Intermediate Factors on Non-Communicable Diseases: A Comprehensive Analysis |
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