| Title: | Associations Between Metabolic Score for Visceral Fat and Venous Thromboembolism Among 118 619 Participants With Metabolic Syndrome: Insights From Epidemiology to Genetic Susceptibility. |
| Journal: | Journal of the American Heart Association |
| Published: | 6 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42089184/ |
| DOI: | https://doi.org/10.1161/jaha.125.044744 |
Publication 20156
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Abstract
BACKGROUND: Metabolic syndrome substantially elevates venous thromboembolism (VTE) risk, increasing health care burdens. The Metabolic Score for Visceral Fat (METS-VF) offers a novel, simplified approach to assess visceral fat. This study evaluates METS-VF's association with VTE risk and its utility for risk stratification in patients with metabolic syndrome.</p>
METHODS: Using UK Biobank data, we included 118 619 participants with metabolic syndrome free of VTE at baseline. Time-dependent area under the curve analysis with bootstrap validation identified the strongest VTE predictor. Multivariable Cox models assessed associations of METS-VF, a VTE-specific polygenic risk score, and their combination with incident VTE. Mediation analysis evaluated potential mediators. Robustness was assessed through subgroup and sensitivity analyses, including competing risk of death.</p>
RESULTS: Over a median 12-year follow-up, 5162 participants developed VTE. METS-VF demonstrated stronger association with VTE than traditional metabolic indicators. Highest quartile participants showed significantly increased risks of VTE (hazard ratio [HR], 1.46 [95% CI, 1.33-1.61]), pulmonary embolism (HR, 1.50 [95% CI, 1.33-1.70]), deep vein thrombosis (HR, 1.52 [95% CI, 1.34-1.73]), and lower-extremity deep vein thrombosis (HR, 1.59 [95% CI, 1.38-1.82]). Stratified analysis revealed synergistic interaction between METS-VF and genetic susceptibility. CRP (C-reactive protein) and estimated glomerular filtration rate significantly mediated the METS-VF-VTE association.</p>
CONCLUSIONS: METS-VF is a significant, independent risk indicator for VTE in patients with metabolic syndrome, demonstrating synergistic effects with genetic risk. The CRP- and estimated glomerular filtration rate-mediated association supports METS-VF's clinical utility in VTE risk stratification.</p>
14 Keywords
- Adult
- Aged
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Intra-Abdominal Fat
- Male
- Metabolic Syndrome
- Middle Aged
- Risk Assessment
- Risk Factors
- United Kingdom
- Venous Thromboembolism
7 Authors
- Lei Liu
- Hongxuan Fan
- Zhaoyu Ren
- Rong Luo
- Huihui Ma
- Hongqiang Ren
- Xiaoping Li
1 Application
| Application ID | Title |
|---|---|
| 106027 | Building a prediction and early warning system of cardiovascular disease based on artificial intelligence |
Enabling scientific discoveries that improve human health