| Title: | Linking accelerated biological ageing to cataract susceptibility: evidence from cross-cohort analysis |
| Journal: | British Journal of Ophthalmology |
| Published: | 7 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42097863/ |
| DOI: | https://doi.org/10.1136/bjo-2025-329061 |
Publication 20148
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Abstract
PURPOSE: The cross-sectional and longitudinal associations between accelerated biological ageing and the risk of cataract and other blinding eye diseases (including glaucoma and age-related macular degeneration (AMD)) remain unclear.</p>
METHODS: We included participants aged 40 and above with biological ages, including phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge) and retinal age (RetiAge), from the US National Health and Nutrition Examination Survey (NHANES) and UK Biobank. The cross-sectional analyses were conducted to identify associations of PhenoAge or KDMAge acceleration with cataract and other blinding eye diseases using logistic regression. In a prospective UK cohort, we explored the relationships between the acceleration of PhenoAge, KDMAge or RetiAge and cataract and other blinding eye diseases using the Cox proportional hazards model.</p>
RESULTS: This study consisted of 5433 participants from the US NHANES and 269 615 participants from the UK Biobank. In both cross-sectional and longitudinal analyses, accelerated biological ageing was positively associated with an increased risk of cataract (all p<0.05). In a longitudinal cohort, RetiAge acceleration demonstrated the larger effect size estimates (HR 1.54 (95% CI 1.38 to 1.73)) compared with PhenoAge acceleration (HR 1.05 (95% CI 1.03 to 1.08)) and KDMAge acceleration (HR 1.06 (95% CI 1.04 to 1.08)). Only in the UK population, risks of glaucoma showed stronger links with KDMAge acceleration (HR 1.06 (95% CI 1.01 to 1.11)), while AMD showed more pronounced associations with PhenoAge acceleration (HR 1.08 (95% CI 1.02 to 1.14)).</p>
CONCLUSIONS: Accelerated biological ageing might represent a potential target of assessment and intervention for cataract.</p>
19 Authors
- Kaiyi Chi
- Yiru He
- Xin Zuo
- Chunran Lai
- Jiahui Cao
- Yican Ying
- Binghua Zhang
- Renyu Li
- Meilin Chen
- Xiaolu Tan
- Qinyi Li
- Shan Wang
- Qiaowei Wu
- Jiayue He
- Lei Liu
- Yijun Hu
- Zhuoting Zhu
- Xiayin Zhang
- Honghua Yu
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
Enabling scientific discoveries that improve human health