| Title: | Mendelian Randomization Reveals Interleukin-6 Receptor-Lipoprotein(a) Interplay With Independent Cardiovascular Risk Reductions |
| Journal: | JACC Basic to Translational Science |
| Published: | 8 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42101392/ |
| DOI: | https://doi.org/10.1016/j.jacbts.2026.101564 |
Publication 20128
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
In the study at hand, 2-sample Mendelian randomization supported a causal effect of interleukin-6 receptor (IL-6R) signaling on Lp(a) concentrations, revealing a direct interplay between 2 causal risk factors for cardiovascular disease (CVD). Importantly, epidemiological analyses in UK Biobank showed that neglecting the IL-6R functional state can confound the association between IL-6 levels and Lp(a). However, the effect of circulating IL-6 on Lp(a) concentrations was modest even when the functional state of the receptor was considered. In line, factorial Mendelian randomization indicated that down-regulation of IL-6R signaling and Lp(a) independently reduce CVD risk, highlighting complementary opportunities for CVD risk mitigation.</p>
8 Authors
- Azin Kheirkhah
- Silvia Di Maio
- Stefan Coassin
- Sebastian Schönherr
- Claudia Lamina
- Lukas Forer
- Florian Kronenberg
- Johanna F Schachtl-Riess
1 Application
| Application ID | Title |
|---|---|
| 62905 | Analyzing unmappable ("camouflaged") genome regions in UK Biobank exome sequencing data using the LPA gene as a model. |
Enabling scientific discoveries that improve human health