| Title: | Circulating levels of insulin-like growth factor binding protein 7 are associated with risks of chronic diseases and death |
| Journal: | npj Aging |
| Published: | 9 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42103769/ |
| DOI: | https://doi.org/10.1038/s41514-026-00400-x |
| URL: | https://www.nature.com/articles/s41514-026-00400-x_reference.pdf |
Publication 20111
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Abstract
Relationships between the concentration of circulating IGFBP-7 and risk of disease and mortality have been suggested by small-scale investigations. In this prospective study, we investigated these relationships among 53,003 UK Biobank participants. Higher IGFBP-7 level was significantly associated with increased risk for liver cancer, all-cause mortality, diabetes, and other diseases. Associations were robust across sex and age groups and persisted over long follow-up. IGFBP-7 polygenic risk scores also predicted cancer and mortality risk. IGFBP-7 level was strongly correlated with levels of previously identified aging-related proteins, but after adjustment for these proteins, remained associated with risk of bladder cancer, liver cancer, multiple myeloma, all-cause mortality, liver-related mortality, and diabetes. Our findings indicate IGFBP-7 as a novel biomarker of mortality and disease risk.</p>
6 Authors
- Zhi Li
- Chengzhe Tao
- Ziyi Zhou
- Michael N. Pollak
- Edward L. Giovannucci
- Mingyang Song
1 Application
| Application ID | Title |
|---|---|
| 46466 | Serum cardiometabolic and liver function markers in relation to colorectal cancer risk and survival |
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