| Title: | Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study |
| Journal: | Frontiers in Nutrition |
| Published: | 13 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42211092/ |
| DOI: | https://doi.org/10.3389/fnut.2026.1802388 |
| URL: | https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1802388/pdf |
Publication 20061
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Background and objective: In 2019, the EAT-Lancet Commission on Healthy Diets from Sustainable Food Systems proposed the EAT-Lancet planetary health diet as a universal reference dietary pattern aimed at promoting human health while minimizing environmental degradation. However, epidemiological evidence regarding the association between adherence to the EAT-Lancet diet and the risk of heart failure (HF), particularly among individuals with cardiovascular-kidney-metabolic syndrome (CKMs) stages 0-3, remains limited. Therefore, this study aimed to examine the associations between adherence to the EAT-Lancet dietary pattern, its individual dietary components, and the risk of HF among individuals at CKMs stages 0-3.</p>
Materials and methods: In this prospective study, a total of 120,849 participants with CKMs stages 0-3 from the UK Biobank cohort were included. Dietary data were collected using an online 24-h dietary recall questionnaire. The EAT-Lancet Diet Index, ranging from 0 to 14, was constructed based on the EAT-Lancet reference diet to evaluate adherence. Cox proportional hazards models and restricted cubic spline functions were used to assess the associations between the EAT-Lancet Diet Index, its dietary components, and HF risk.</p>
Results: Over a median follow-up of 14.88 years, 2,454 participants developed HF. A higher EAT-Lancet Diet Index was significantly associated with a lower risk of HF compared to the lowest index group (hazard ratio [HR]: 0.88; 95% confidence interval [CI]: 0.80, 0.97). This association remained robust across subgroup and multiple sensitivity analyses. Restricted cubic spline analysis revealed a significant inverse linear relationship between the EAT-Lancet Diet Index and HF risk. Among dietary components, reduced intake of red meat (beef, lamb, and pork) (HR: 0.90; 95% CI: 0.83, 0.98) and increased intake of peanuts or other nuts (HR: 0.76; 95% CI: 0.60, 0.95) were significantly associated with lower HF risk.</p>
Conclusion: This study demonstrates that greater adherence to the EAT-Lancet diet is significantly associated with a reduced relative hazard of HF among individuals with CKM stages 0-3, particularly through reduced consumption of red meat and increased intake of peanuts or other nuts.</p>
12 Authors
- Peng Fu
- Hong Zheng
- Kuangyi Wu
- Yulong Lan
- Dan Wu
- Weiqiang Wu
- Huancong Zheng
- Zefeng Cai
- Yuxian Wang
- Qiuyue Lin
- Bo Zhang
- Youren Chen
1 Application
| Application ID | Title |
|---|---|
| 156009 | Roles of clinical, lifestyle, environmental, proteome, and genetic factors in prevention, risk prediction and precision treatment of chronic noncommunicable diseases. |
Enabling scientific discoveries that improve human health