| Title: | Bidirectional association between breast cancer and cardiovascular disease: Longitudinal analysis of UK Biobank data |
| Journal: | Atherosclerosis |
| Published: | 14 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42140725/ |
| DOI: | https://doi.org/10.1016/j.atherosclerosis.2026.120662 |
Publication 20026
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Abstract
BACKGROUND AND AIMS: Breast cancer (BC) and cardiovascular disease (CVD) are leading causes of death in women. However, their bidirectional relationship and key risk factors remain unclear.</p>
METHODS: This matched, prospective cohort study using UK Biobank data evaluated the association between BC and CVD, constructing two propensity-score-matched cohorts: 5318 women with BC and 36,857 with CVD, each 1:1 matched to women without the condition (total n = 10,636 and 73,714). Primary outcomes were incident CVD in the BC cohort, incident BC in the CVD cohort, and all-cause mortality in both cohorts. Cox proportional hazards, subgroup analyses, and multi-state models were used to examine the relationship between the two diseases and their stage-specific risks.</p>
RESULTS: The mean age was 58.5 years in the BC cohort and 59.3 years in the CVD cohort, with median follow-up of 12.8 and 13.6 years. BC survivors had a higher risk of CVD (HR = 1.238, 95% CI: 1.205 to 1.273), especially atrial fibrillation and heart failure, while ischemic heart disease and myocardial infarction risks were lower. Conversely, CVD patients had a higher BC risk (HR = 1.446, 95% CI: 1.332 to 1.570). CRP and central obesity were consistent bidirectional risk factors, while BMI, lifestyle, socioeconomic status, and medication use had stage-specific effects.</p>
CONCLUSIONS: This study provides longitudinal evidence for a bidirectional relationship between BC and CVD, with transition probabilities significantly modulated by stage-specific risk profiles.</p>
15 Keywords
- Aged
- Biological Specimen Banks
- Breast Neoplasms
- Cardiovascular Diseases
- Female
- Humans
- Incidence
- Longitudinal Studies
- Middle Aged
- Prospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- UK Biobank
- United Kingdom
13 Authors
- Zijia Liu
- Fengjun Du
- Chunhua Zhao
- Chunxiao Xu
- Zhentao Fu
- Yongna Fan
- Bingyin Zhang
- Xinhai Huang
- Zilong Lu
- Fan Jiang
- Yueqing Huang
- Xiaolei Guo
- Jixiang Ma
1 Application
| Application ID | Title |
|---|---|
| 104283 | Identification of shared risk factors and gene-environment interactions for cardiometabolic diseases and cardiometabolic multimorbidity |
Enabling scientific discoveries that improve human health