| Title: | Effect of accelerometer-measured physical activity on the association between atrial fibrillation and risk of dementia |
| Journal: | The Journal of Prevention of Alzheimer's Disease |
| Published: | 19 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42155558/ |
| DOI: | https://doi.org/10.1016/j.tjpad.2026.100603 |
Publication 19991
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Abstract
BACKGROUND: Atrial fibrillation (AF) independently increases dementia risk, but whether accelerometer-measured physical activity (PA) modifies this association remains unquantified, particularly against self-reported PA limitations.</p>
METHODS: Prospective analysis of 91,795 UK Biobank participants with valid accelerometer data (median age 57, 42.9 % male; 2800 with baseline AF). We categorized whether measured activity met the standard recommendation [moderate-to-vigorous physical activity (MVPA) >_150 min/week]. Questionnaire-derived MVPA data from 353,643 UK Biobank participants (median age 57, male: 46.7 %) between 2006 and 2010 were used for validation. The primary outcome was the diagnosis of incident all-cause dementia. We also assessed correlation between accelerometer-derived and self-reported activity.</p>
RESULTS: Over 7.6-year median follow-up, AF was significantly associated with a higher dementia risk [Adjusted hazard ratio (aHR): 1.76, 95 % confidential interval (CI): 1.51-2.05]. Guideline-adherent PA was associated with a lower AF-related dementia risk to non-significance (aHR: 1.36, 95 %CI: 0.96-1.91). Moreover, PA may be associated with higher protection effect on dementia risk in AF patients (aHR: 0.55, 95 % CI: 0.33-0.92) than in non-AF (aHR: 0.81, 95 % CI: 0.69-0.96), although without statistical difference (Pinteraction = 0.213). Correlation between accelerometer-derived and selfreported MVPA was weak (Spearman r = 0.155, 95 % CI: 0.148-0.162). Self-reported activity was not associated with a decreased risk of dementia in both AF and non-AF participants.</p>
CONCLUSION: Higher accelerometer-measured PA is associated with lower AF-associated dementia risk. Future prospective studies with extended follow-up and serial activity monitoring are needed to confirm these findings.</p>
12 Authors
- Le Li
- Mengtong Xu
- Lingmin Wu
- Zhicheng Hu
- Limin Liu
- Likun Zhou
- Minghao Zhao
- Yulong Xiong
- Zhenhao Zhang
- Lihui Zheng
- Ligang Ding
- Yan Yao
1 Application
| Application ID | Title |
|---|---|
| 394593 | Association of migraine and cardiac arrhythmias |
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