| Title: | Associations of accelerated phenotypic aging, genetic risk and lifestyle with incident asthma, subsequent cardiovascular disease and death: A prospective study using multi-state model |
| Journal: | Maturitas |
| Published: | 20 May 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42184546/ |
| DOI: | https://doi.org/10.1016/j.maturitas.2026.108981 |
Publication 19981
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
OBJECTIVES: To investigate the associations of phenotypic age acceleration (PhenoAgeAccel) with the risk of dynamic progression of asthma, and whether genetic risk and lifestyle influence these associations.</p>
STUDY DESIGN: This prospective cohort study included 320,337 adults without asthma and cardiovascular disease (CVD) from the UK Biobank. PhenoAgeAccel was calculated from chronological age and nine clinical biomarkers, and categorized into two groups: biologically younger (negative value) and biologically older (positive value).</p>
MAIN OUTCOME MEASURES: The primary outcomes were incident asthma, CVD, and all-cause mortality. A multi-state model was used to estimate the hazard ratios (HRs) of these associations.</p>
RESULTS: During a median 13.69-year follow-up, 9073 participants developed asthma, of whom 2061 subsequently developed CVD, and 23,401 died. Compared with biologically younger participants, biologically older participants had significantly higher risks for all transitions: from healthy to asthma (HR 1.29, 95% CI 1.23-1.34) and death (1.59, 1.54-1.63), from asthma to post-asthma CVD (1.28, 1.17-1.40) and death (1.37, 1.09-1.71), and from post-asthma CVD to death (1.44, 1.17-1.76). Biologically older participants with high genetic risk had higher risks of asthma (2.71, 2.46-2.98) and post-asthma CVD (1.91, 1.57-2.33) than biologically younger participants with low genetic risk. Compared with biologically younger participants with favorable lifestyles, biologically older participants with unfavorable lifestyles had higher risks of all transitions, with HRs ranging from 1.56 (1.21-2.02) to 3.43 (3.18-3.69).</p>
CONCLUSIONS: PhenoAgeAccel was significantly associated with increased risks of all disease-state transitions. It could be combined with genetic risk to identify participants at high risk for asthma and its adverse progression, potentially guiding targeted preventive interventions.</p>
4 Authors
- Fan Liu
- Lulu Pan
- Hongxian Wu
- Yongfu Yu
1 Application
| Application ID | Title |
|---|---|
| 96511 | Investigating the genome-wide association and risk factors for multi-organ ageing |
Enabling scientific discoveries that improve human health