| Title: | Sweetened beverage intake and risk of incident kidney stone: results from the UK Biobank |
| Journal: | Frontiers in Nutrition |
| Published: | 21 May 2026 |
| DOI: | https://doi.org/10.3389/fnut.2026.1844118 |
| URL: | https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1844118/pdf |
Publication 19961
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Abstract
Background
To investigate the associations between consumption of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and natural juices (NJs) and incident kidney stone disease (KSD), and to assess whether genetic susceptibility modifies these associations.</p>Methods
We conducted a prospective cohort study of 191,863 UK Biobank participants free of KSD at baseline. Beverage consumption was assessed using web-based 24-h dietary recalls (2009-2012), categorized as 0, 0.1-1.0, 1.1-2.0, and >2.0 units/day (1 unit = 250 ml). A polygenic risk score (PRS) comprising 22 single nucleotide polymorphisms quantified genetic susceptibility. Multivariable Cox regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), with gene-environment interactions evaluated through stratified analyses.</p>Results
During 13.5 years mean follow-up, 2,024 incident KSD cases occurred. Compared with non-consumers, participants consuming >2 units/day of SSBs had 51% higher KSD risk (HR 1.51, 95% CI 1.17-1.95) with significant dose-response relationship (P for trend < 0.001). ASBs showed elevated risk at 1.1-2.0 units/day (HR 1.25, 95% CI 1.02-1.28) without linear trend (P = 0.192). NJs showed no significant association (P for trend = 0.419). Higher PRS independently predicted KSD risk but did not significantly modify beverage-KSD associations (all P for interaction >0.05). Joint analyses revealed highest KSD hazard among participants with high SSB intake and low PRS (HR 2.09, 95% CI 1.46-2.98).</p>Conclusion
Higher SSB consumption is dose-dependently associated with increased KSD risk, while ASBs show non-linear associations and NJs demonstrate no significant association. Genetic susceptibility independently predicts KSD risk but does not substantially modify beverage-KSD relationships. Limiting SSB intake represents an important modifiable strategy for KSD prevention independent of genetic predisposition.</p></p>
6 Authors
- Binxian Ye
- Yueming Liu
- Jinshi Zhang
- Jianguang Gong
- Bin Zhu
- Wangfang Chen
1 Application
| Application ID | Title |
|---|---|
| 545732 | Study on the Impact of Genetic Variation, Environmental Exposure, and Lifestyle Behaviors on Disease Progression and Health Outcomes in Patients with Chronic Infectious Diseases |
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