| Title: | Accelerometer-derived physical activity associated with incident probable sarcopenia, fracture, and falls |
| Journal: | American Journal of Preventive Medicine |
| Published: | 8 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41962692/ |
| DOI: | https://doi.org/10.1016/j.amepre.2026.108370 |
Publication 18061
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Abstract
INTRODUCTION: The reported associations between physical activity (PA) type, intensity, and duration with decreased risks of developing sarcopenia, fractures, and falls are inconsistent. Therefore, the associations of accelerometer-derived PA data with probable sarcopenia, fractures, and falls risk were examined.</p>
METHODS: A total of 80,804 participants with accelerometer-derived PA data from the UK Biobank were included. The primary outcomes were probable sarcopenia, fractures, and falls, with recurrent fractures and falls as secondary outcomes. Cox proportional hazards models were used to estimate the associations between total/intensity-specific PA and the outcomes, and restricted cubic splines were used to investigate dose-response relationships.</p>
RESULTS: There were 1,949 probable sarcopenia, 4,174 fractures, and 3,514 falls in the accelerometer-derived cohort. Performing guideline-adherent moderate to vigorous-intensity PA (MVPA) (150-300 min/week) was associated with lower risks of 30% for probable sarcopenia [hazard ratio (HR): 0.70 (0.53-0.91)], 41% for fractures [HR: 0.59 (0.51-0.68)], 47% for falls [HR: 0.53 (0.47-0.61)], 40% for recurrent fractures [HR: 0.60 (0.45-0.81)], and 47% for recurrent falls [HR: 0.53 (0.46-0.62)]. A low dose of vigorous-intensity PA (0-25 min/wk) could yield apparent benefits on incident probable sarcopenia, fractures, and falls.</p>
CONCLUSIONS: Engaging in multiple types of PA, particularly higher levels of MVPA, was associated with a lower risk of developing probable sarcopenia, fractures, and falls.</p>
9 Authors
- Fa Shen
- Yu-Yang Liu
- Jia-Qi Yang
- Hao-Yu Liu
- Li-Wen Zhang
- Qian-Man Li
- Ting-Ting Gong
- Qi-Jun Wu
- Shan-Yan Gao
1 Application
| Application ID | Title |
|---|---|
| 211772 | Understanding the role of modifiable and genetic factors with sarcopenia in UK biobank: a longitudinal analysis |
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