| Title: | Association of lifestyle factors and genetic risk with incident abdominal aortic aneurysm |
| Journal: | Journal of Vascular Surgery |
| Published: | 10 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41967726/ |
| DOI: | https://doi.org/10.1016/j.jvs.2026.03.619 |
Publication 18037
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Abstract
BACKGROUND: Although lifestyle factors are associated with the risk of abdominal aortic aneurysm (AAA), its relationship with genetic susceptibility in determining AAA remains unclear. We aim to investigate the association of lifestyle factors and genetic risk with the incidence of AAA.</p>
METHODS: A prospective cohort study, including 274,755 adult participants with white European ancestry and no AAA at baseline, was recruited between 2006 and 2010. A polygenic risk score (PRS) was calculated to quantify genetic susceptibility to AAA in participants, and a comprehensive healthy lifestyle score was derived based on factors including sleep, diet, alcohol consumption, physical activity, waist-to-hip ratio, and smoking. Incident AAA, determined by linking medical history with hospital admission and death registries.</p>
RESULTS: Participants at high genetic risk had an 89% higher risk of AAA compared with those at low genetic risk. A poor lifestyle was associated with a 165% increased risk of developing AAA compared with a healthy lifestyle. Participants with both a poor lifestyle and high genetic risk exhibited the highest risk, with a hazard ratio for incident AAA of 4.64 [95% confidence interval (CI): 2.59, 8.31] compared with those at low genetic risk and a healthy lifestyle. Moreover, there was a significant positive additive interaction between poor lifestyle and high genetic risk (relative excess risk due to interaction: 1.81; 95% CI: 0.69, 2.92).</p>
CONCLUSION: High genetic risk and poor lifestyle were both independently and jointly associated with an increased risk of AAA. Moreover, following a healthy lifestyle can reduce the risk of AAA for individuals, particularly among those with high genetic risk.</p>
11 Authors
- Jingyi Ren
- Zhenao Zhang
- Xiaoya Sun
- Huanting Pei
- Yadong Zhang
- Chongyue Zhang
- Xiaolong Zhang
- Simeng Qiao
- Siqi Zhu
- Bowen Yin
- Yuxia Ma
1 Application
| Application ID | Title |
|---|---|
| 471488 | Association between factors influencing the life course and the occurrence and progression of chronic noncommunicable diseases |
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