| Title: | Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis |
| Journal: | Rheumatology |
| Published: | 13 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41978544/ |
| DOI: | https://doi.org/10.1093/rheumatology/keag179 |
| URL: | https://doi.org/10.2139/ssrn.5132603 |
Publication 18006
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Abstract
OBJECTIVE: To explore the associations between accelerometer-measured physical activity patterns and cardiovascular diseases (CVD), CVD-cause mortality, and all-cause mortality in people with osteoarthritis (OA).</p>
METHODS: OA participants from the UK biobank with ≥36 h of accelerometer data, collected over one-week, were analyzed. Moderate to vigorous physical activity (MVPA) patterns were classified as: 'weekend warriors' (≥150 min/week, >50% on 1-2 days), active regular (>150 min/week), or inactive (<150 min/week). Mean min per week of light physical activity (LPA) were categorized into quartiles based on the distribution in the analytical sample.</p>
RESULTS: Among 10 210 study participants (mean age 58.1 ± 7.1 years; 64.5% female) followed for a median of 6.9 years, there were 1,538 incident cases of CVD, and 358 deaths, including 90 from CVD. Compared with inactive MVPA, both weekend warrior (adjusted hazard ratio, aHR (95% CIs); 0.73 (0.64-0.82)) and active regular MVPA (0.75 (0.65-0.87)) significantly lowered the risks of incident CVD. Notably, only the weekend warrior group showed significant reductions in CVD-cause mortality (0.55, 0.33-0.92), and all-cause mortality (0.75 (0.59-0.96)). Higher levels of LPA may link to lower CVD, CVD-cause mortality, and all-cause mortality risks in a dose-response manner. Subgroup analysis indicated that more prominent associations were found in individuals with a body mass index >30 or those aged over 60.</p>
CONCLUSION: Engaging in a weekend warrior pattern may confer unique survival benefits for OA patients, especially among older adults and those with obesity. LPA may have dose-dependent protective effects for CVD and mortality risk in OA patients.</p>
16 Authors
- Tianxiang Fan
- Qiyu Xie
- Jiawei Chen
- Muhui Zeng
- Shibo Chen
- Hao Yang
- Guangfeng Ruan
- Qian Yang
- Yujie Zhang
- Ye Li
- Peihua Cao
- Kim L Bennell
- Siu Ngor Fu
- David J Hunter
- Changhai Ding
- Zhaohua Zhu
1 Application
| Application ID | Title |
|---|---|
| 67654 | Genetic risk factors, environmental factors, and the gene-environment interactions in osteoarthritis |
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