| Title: | Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK. |
| Journal: | British Journal Of Nutrition |
| Published: | 29 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42051084/ |
| DOI: | https://doi.org/10.1017/s0007114526107351 |
Publication 17800
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Abstract
Mediterranean diet (MedDiet) is central to MASLD management, however evidence in non-Mediterranean populations is limited. This study examined the association between MedDiet adherence and MASLD, hospitalisation, and mortality in a non-Mediterranean population. This longitudinal study included 119,536 UK Biobank adults with at least one 24-hour dietary recall and available sociodemographic and clinical data. Diet quality was assessed using the Modified-Mediterranean Diet Score (M-MedDietScore). MASLD was determined by Fatty Liver Index (FLI) at baseline and by liver imaging in a subgroup. Hospitalisation and mortality data were obtained from linked records, with MASLD outcomes identified using ICD-10 codes. Binary logistic regression and Cox proportional hazard models estimated odds ratios (OR) for MASLD and hazard ratios (HR) for hospitalisation and mortality. Each five-unit increase in M-MedDietScore was associated with 19% lower OR of MASLD as identified by FLI and confirmed in the imaging sub-analysis in a multivariate adjusted Model 2. Higher adherence to the MedDiet was associated with lower HR of hospitalisation due to liver-related, cardiovascular disease (CVD), diabetes, respiratory and renal disease (all p < 0.05). During a median follow-up of 9.7 years, 5,552 deaths occurred. Higher MedDiet adherence was associated with lower HR of all-cause, CVD, and extrahepatic cancer mortality and lower all-cause mortality risk in those with MASLD (HR: 0.94, 95% CI: 0.90-0.98). Higher adherence to the MedDiet was associated with lower off of MASLD and with reduced MASLD-related hospitalisations and mortality and lower all-cause mortality in those with MASLD. These findings support the role of MedDiet in reducing hepatic and cardiovascular burden in non-Mediterranean population.</p>
7 Authors
- Elena S George
- Ayesha Sualeheen
- Christine Freer
- Ekavi N Georgeousopoulou
- Stuart K Roberts
- Robin M Daly
- Sze-Yen Tan
1 Application
| Application ID | Title |
|---|---|
| 479734 | Correlation and causal relationship of Blood lipids and metabolites, healthy lifestyle and socioeconomic status with prevalence and mortality of metabolic disease. |
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