| Title: | Influence of serum lipids and polyunsaturated fatty acids on rosacea: Insights from prospective cohort studies |
| Journal: | JDDG Journal der Deutschen Dermatologischen Gesellschaft |
| Published: | 15 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41691421/ |
| DOI: | https://doi.org/10.1111/ddg.15978 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ddg.15978 |
Publication 17755
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Abstract
BACKGROUND AND OBJECTIVES: Recent studies have suggested potential links between dermatological conditions, dyslipidemia, and cardiovascular health, yet the relationship between serum lipids and rosacea remains uncertain.</p>
PATIENTS AND METHODS: Utilizing data from UK Biobank, we employed Cox proportional hazard models to evaluate the correlation between rosacea and serum lipids, with mediation analysis further elucidating the underlying mechanisms. Additionally, two-sample Mendelian randomization and linkage disequilibrium score regression were performed to determine the genetic association.</p>
RESULTS: In both the blood biochemistry cohort and the nuclear magnetic resonance metabolome cohort, higher levels of total cholesterol, LDL, and cholesterol in large LDL were inversely associated with rosacea (HR = 0.90 [0.85-0.95], 0.91 [0.86-0.96], and 0.90 [0.85-0.95], respectively). Additionally, omega-3 was found to potentially reduce the risk of rosacea by increasing cholesterol levels in large LDL (OR = 0.88 [0.82-0.94]; mediated proportion = 61.56%). Mendelian randomization analyses further supported the protective effects of total cholesterol and cholesterol in large LDL against rosacea (OR = 0.70 [0.55-0.89] and 0.79 [0.62-0.99], respectively).</p>
CONCLUSIONS: These findings suggest that higher levels of total cholesterol and cholesterol in large LDL may decrease rosacea risk, while omega-3 could influence rosacea pathogenesis through modulation of cholesterol in large LDL.</p>
5 Authors
- Rui Mao
- Qinyang Yu
- Tongtong Zhang
- Xin Meng
- Ji Li
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