| Title: | The influence of multiple air pollutants on sarcopenia progression: A multi-state analysis in a prospective cohort |
| Journal: | The Journals of Gerontology Series A |
| Published: | 17 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41701152/ |
| DOI: | https://doi.org/10.1093/gerona/glag052 |
Publication 17735
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Abstract
BACKGROUND: Air pollution's influence on sarcopenia progression remains insufficiently studied.</p>
METHODS: Using the UK Biobank cohort, we included 50,381 participants initially free of probable sarcopenia and sarcopenia. Exposures to PM2.5, PM10, PM2.5-10, NO2, and NOx for each transition stage were estimated at each participant's residential addresses using data from the UK's Department. Parametric g-computation was applied to estimate cumulative risks under hypothetical pollution reduction scenarios. Multi-state models were used to examine associations between air pollution and sarcopenia progression.</p>
RESULTS: During 8.98 years (median), 4,445 (8.8%) participants developed probable sarcopenia; 17 (0.4%) progressed to sarcopenia. Parametric g-computation estimated that a simultaneous 10% reduction in all four pollutants would decrease the 15-year cumulative risk (Risk Ratio [RR] = 0.93; Risk Difference [RD] = -2.21). In multi-state models, PM2.5 increased risks of probable sarcopenia (hazard ratio [HR]: 1.06; 95% confidence interval [CI)]: 1.02-1.10), sarcopenia (HR: 1.18; 95%CI: 1.04-1.34), baseline to death (HR: 1.11; 95%CI: 1.02-1.20) and probable sarcopenia to death (HR: 1.24; 95%CI: 1.04-1.50). NO2 showed similar associations: probable sarcopenia (HR: 1.06; 95%CI: 1.02-1.10), sarcopenia (HR: 1.23; 95%CI: 1.09-1.39), baseline to death (HR: 1.10; 95%CI: 1.01-1.19) and probable sarcopenia to death (HR: 1.23; 95%CI: 1.01-1.50). NOx increased risks for probable sarcopenia (HR: 1.06; 95%CI: 1.03-1.09), sarcopenia (HR: 1.15; 95%CI: 1.04-1.26) and probable sarcopenia to death (HR: 1.22; 95%CI: 1.04-1.43). Stratified analyses indicated effect modification by sex, household income, and BMI.</p>
CONCLUSIONS: These findings highlight the critical role of clean air in preventing and delaying sarcopenia progression, especially in vulnerable populations.</p>
12 Authors
- Ni Sang
- Xingyue Dai
- Qiaoling Yang
- Meiqin Nie
- Wenchen He
- Zhaoliang Wang
- Hui Liu
- Yajuan Duan
- Qiao Liu
- Lu Han
- Guocui Wu
- Li Cheng
1 Application
| Application ID | Title |
|---|---|
| 80827 | Dissecting the relationships between autoimmune rheumatic diseases and cancer |
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